The findings appeared in the Journal of Nature Nanotechnology. They are also known to play a role in the development of rheumatoid arthritis, a chronic autoimmune disease that causes painful inflammation in the lawn mower throttle cable Manufacturers joints and can ultimately lead to damage of cartilage and bone tissue.The nanosponges essentially nip this inflammatory cascade in the bud. Mixing them with ball-shaped nanoparticles made of biodegradable polymer fused the neutrophil cell membranes onto the nanoparticle surfaces.
The nanosponges also worked as a preventive treatment when administered prior to inducing the disease. Administering the nanosponges early on, also prevented the disease from developing.To make the neutrophil nanosponges, the researchers first developed a method to separate neutrophils from whole blood.Nanosponges are nano-sized particles designed to look like red blood cells and protect the body."Nanosponges are a new paradigm of treatment to block pathological molecules from triggering disease in the body.
Neutrophils are among the immune systems first responders against invading pathogens. Rather than creating treatments to block a few specific types of pathological molecules, we are developing a platform that can block a broad spectrum of them, and this way we can treat and prevent disease more effectively and efficiently," said senior author Liangfang Zhang.Injections of these nanosponges are known to be effective while treating severe rheumatoid arthritis.
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